Vincenzo Natali (Cube) directs and Guillermo Del Toro produces this twisted tale of a pair of rebellious scientists (Sarah Polley & Adrien Brody) who defy legal and ethical boundaries to forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named “Dren,” the creature rapidly develops from a deformed female infant into a beautiful human-chimera. The pair raise the creature as their own, but as Dren reaches maturity, their bond takes a turn towards the depraved and the deadly.